PMBCL: a molecular diagnosis?

Molecular Diagnosis of Familial Hypercholesterolemia

Abstract Background and objectives: Familial hypercholesterolemia (FH) is an autosomal disorder characterized by increased levels of total cholesterol and low density lipoprotein cholesterol. The FH clinical phenotype has been associated with increased risk of coronary heart disease and premature death. The mutation in LDLR gene in most cases is responsible for FH phenotype. Furthermore, other ...

Distinguishing PMBCL from other forms of DLBCL can be viewed as a paradigm for reclassification of cancer subtypes based on molecular features, as the molecular characterization of PMBCL highlighted an overlap with the nodular sclerosis

Molecular imaging approaches in the diagnosis of breast cancer: A systematic review and meta-analysis

Introduction:The accuracy of positron emission tomography with computed tomography (PET/CT), positron emission mammography (PEM), and breast specific-gamma imaging (BSGI) in diagnosing breast cancer has never been systematically assessed, the present systematic review was aimed to address this issue.  Methods:PubMed, Scopus and EMBASE were searched for st...

A molecular prevalence of Blastocystis hominis in patients referred to medical diagnosis laboratories in Khorramabad city

Background : Blastocystis hominis is an anaerobic, zoonotic protozoan parasite which inhabits the large intestine of humans and a wide range of other vertebrates. It has a worldwide distribution and infects hosts through the cyst of the parasite by contaminated water or food. Its prevalence is related to hygienic culture, season, exposure to animals, and age. A number of studies in the last dec...

Gene assembling: a new approach in molecular diagnosis of hereditary breast cancer

 Abstract Background: Many disease susceptibility genes are large and consist of many exons in which point mutations are scattered throughout. Scanning each exon individually represents a tedious task which can be time consuming and expensive. There has been increasing demand for rapid and accurate methods for full scanning of unknown point mutations in large multi-exon genes. Gene Assembling i...